الفهرس 
INTRODUCTIONOnly 14 pages are availabe for public view
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Abstract
New three simple and accurate spectrophotometric or atomic absorption spectrometric (AAS) methods have been developed for the determination of gemifloxacin mesylate (GMF), moxifloxacin HCl (MXF) and enrofloxacin (ENF) in pure and dosage forms or spiked human urine. The first method is based on the formation of ion-pair associates between the GMF and ENF and the inorganic complex, bismuth (III) tetraiodide. The reaction occurs in acidic medium to form orange-red ion-pair associates which are instantaneously precipitated. The formed precipitates are then filtered off and the residual unreacted metal complex in the filtrate is determined spectrophotometrically at 463 nm or by AAS at 223 nm. Also, the precipitates may be dissolved in acetone and quantified spectrophotometrically at 492 and 494 nm for GMF and ENF, respectively or decomposed by hydrochloric acid and the bismuth content is determined by AAS at 223 nm. The methods permit the determination of the two studied drugs in the range of 8.0-80 μg mL-1. The second method are based on the formation of yellow colored chloroform ion-pair complexes between the three studied drugs and acid dyes, namely; bromocresol green (BCG), bromocresol purple (BCP), bromophenol blue (BPB), bromothymol blue (BTB) and methyl orange (MO), in acidic buffer of pH range (3.0-3.5). The formed complexes were extracted with chloroform and measured at 420, 408, 416, 415 and 422 nm using BCG, BCP, BPB, BTB and MO respectively for GMF; at 410, 415, 416, and 420 nm using BCP, BTB, BPB and MO, respectively for MXF and at 419 and 414 nm for BCG and BTB, respectively for ENF. Beer’s law was obeyed in the range 1.0–30 µg mL−1.