الفهرس 
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Abstract
Group B streptococcus (GBS)infection is one of the
leading causes of morbidity and mortality in newborns and is
the main etiological factor for neonatal bacterial sepsis . The
organism responsible for the infection, streptococcus agalactiae,
inhabits the maternal genitourinary and gastrointestinal tract of
pregnant women and is usually asymptomatic. However, GBS
might result in puerperal endometritis especially following a
cesarean delivery. In pregnant women, GBS is a frequent cause of urinary
tract infection, chorioamnionitis, postpartum endometritis, and
bacteremia. In neonates, GBS infection is acquired in utero
during passage through the vagina. Neonatal infection appears
in the form of bacteremia, meningitis or other focal infections. A number of perinatal factors are claimed in about ٩٠%
of early onset GBS disease and a lower proportion of late onset
infection, such as maternal GBS colonization, well-defined
perinatal factors and absence of antibody to GBS. Streptococcus agalactiae is a leading cause of sepsis and
meningitis in neonates. Neonatal GBS disease presents as earlyonset
disease
or
late
– onset disease. In early- onset disease (age at onset ٠-٦ days), the neonate is infected by exposure to GBS
before or during birth. For late- onset disease (٧-٨٩ days), the
pathogenesis is not clear. This work aimed to determine the rate of GBS
colonization in pregnant women and their neonates and the risk
factors associated with GBS infection. The study included ٧٠ pregnant women who attended
antenatal care and delivery room at the Gynecology at
Obstetric Hospitals of Ain Shams University and their
neonates. They were subjected to full history taking, completclinical examination, two sets of vaginal swabs were also
taken.
The first set was cultured on blood agar media and
subjected to conventional identification methods i.e., direcfilm catalase test, CAMP test and API test. The second set was cultured on Islam agar media which
s a culture provided for GBS isolation. We got the results ٢٤h
sooner, it have the great advantage of detecting GBS growth
by the production of orange pigmented colonies. In our study eight (١١٫٤%)women and two (٣%)neonates
were found to be colonized with GBS.
All of colonized neonates were born to colonized women.
There was a high significant association of age and parity with
GBS colonization. Increasing age of pregnant women increases
the probability of being a GBS carrier.
Using IUD, history of UTI and DM are factors that have
been reported to influence the prevalence of GBS colonization
in our study.