الفهرس 
Epidomology of cancer
Materials & MethodsOnly 14 pages are availabe for public view
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Abstract
A diminished amount of antioxidant enzyme coupled with superoxide
production in appears to be general characteristic of the tumor cells. This character
can be used in cancer treatment, Thus present study attempted to investigate the effect
of 4-Azomalanonitrileantipyrine copper and cobalt complexes which have SOD like
activity on tumor development using Ehrlich ascites carcinoma (EAC) implemented
in Swiss albino female mice.
Accordingly, the mice were classified into seven groups of ten animals in each
group as follows: Group 1; normal mice injected with 0.9 % NaCl saline solution.
Group 2; normal mice injected with complex solvent (Di-methyl sulphoxide).Group
3; normal mice injected with copper complex. Group 4; normal mice injected with
cobalt complex.Group-5; Earlich ascites carcinoma (EAC) without treatment. Group
6; Earlich ascites carcinoma (EAC) treated with copper complex and Group 7; Earlich
ascites carcinoma (EAC) treated with cobalt complex.
The following parameters were determined:
1. Life span prolongation of the tumor-bearing which would evidence the
antitumor activity of these complexes.
2. Serum creatinine, Hb, GPT, and GOT were carried out as parameter to drug
toxicity and follow the clinical status of the treated animals as well as its
extent of responsiveness to treatment.
3. The Nitric oxide, MDA and the activities of antioxidant and glutathionerelated
enzyme activity as well as the reduced glutathione content which
would partly highlight the mode of action of the tested complexes.
4. Histopathology upon treatment with theses complexes.
5. Effects of these complexes on the DNA content and Cell cycle by Flow
cytometery which would partly highlight the mode of action of the tested
complexes.