الفهرس 
Introduction and AIM of the WorkOnly 14 pages are availabe for public view
 |  | from | 171 |  |  |
| | | from | 171 | | |
Abstract
The current study was carried out in the department of cardiology El-Minya University during the period from 8/2011 to 7/2012 on 43 patients with Non-ST segment-elevation acute coronary syndrome (NSTEACS)
:{Unstable angina (UA) & Non ST segment elevation myocardial infarction (NSTEMI )} admitted to coronary care unit. Patients were classified into 2 groups on the basis of the result of troponin into NSTEMI it includes 31 patients , and UA it includes 12 patients. Venous blood samples of the Non-st-elevation ACS group were drawn after admission in a fasting state .The time interval between symptom onset and blood sampling was less than 48 hours in all cases with a median at 21 hours. serum leptin level was measured. Coronary angiography was performed , Lesions were assessed according to Syntax score. Low SYNTAX scores are <18, intermediate SYNTAX scores range from 18-27 and high SYNTAX scores are >32 . Leptin ,is a recently discovered obesity gene product, recent observations suggest that leptin has a much broader biological role othe than regulation of body weight and energy metabolism. By activating different immune/ inflammatory cells or directly acting on vessel wall leptin has been shown to play a potential role in the development of ACS In this study We found that the concentration of leptin were higher in the (UA) , (NSTEMI ) groups having angiographically visible complex lesions than in the same groups with simple lesions, significant positive correlation between Leptin and the complexity of coronary angiographic findings ( p value = 0.001). Clinical studies have shown the presence of these angiographically visible complex lesions as having a multitude of adverse outcomes, with the possibility that these types of lesions might predict myocardial infarction. The presence of complex lesions is also seen to be associated with higher complication rates following angioplasty in patients with NSTE-ACS 1-We believe more approaches aimed at reducing plasma leptin levels or blocking its action on immune cells would be useful in the prevention or inhibition of atherosclerotic lesions, and restoration of normal leptin levels may therefore help to reduce the mortality and morbidity associated with ACS. 2- Further long term studies may be needed with a large number of patients to confirm that leptin can be used as an independent predictor for the complex lesion morphology in patients with NSTE-ACS 3- Assay of serum leptin in patients with NSTE-ACS as a useful biomarker for risk stratification.