الفهرس 
Rationale for Chemoradiation TherapyOnly 14 pages are availabe for public view
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Abstract
The impotance of combined modality chemo-radiotherapy is to achieve overall survival comparable to and can replace primary surgery while maintaining organ function and play a major rule in the improvement in QOL of the cancer patient after treatment.
Assessment of Drug Radiation Interaction through Increasing Initial Radiation Damage, Inhibition of Cellular Repair, Cell Cycle Redistribution, Counteracting Hypoxia - Associated Tumor Radioresistance and Inhibition of Tumor Cell Repopulation.
Many trials prefer the use of concurrent or concomitant chemo-radiotherapy for locoregional control with best result for organ preservation but associated with increased toxicity.
Normal tissue toxicity represents a major limitation of concurrent chemoradiation therapy through the incorporation into the treatment of chemoprotective agents (Amifostine only radioprotector currently in clinical use, Tempol, glutathione, lipoic acid, vitamins A, C, E, melatonin, KGF, GM-CSF and G-CSF) or through improvements of radiation delivery ( IMRT and IGRT). Radiosensitizers play important rule in increasing the damage to the tumor cell in compination with radiation as (Platinum-Based Drugs, Taxanes, Mitomycin C, Antimetabolites, Topoisomerase I Inhibitors, Temozolomide, EGFR inhibitor, Cyclooxygenase-2 inhibitor, VEGFRs inhibitor, NFκB Inhibitors, mTOR inhibitors and (PARP-1) inhibitors.
The use of concomitant chemo-radiotherapy in treatment of patients with head and neck cancers can avoid disfigurement, voice loss, difficulty with chewing and/or swallowing and respiratory problems that result from surgical resection and associated with moderate to severe distress, negative self image, and disturbed interpersonal relationships.
In treatment of cancer rectum and anal canal colostomy-free survival is a measure of anal sphincter preservation after treatment with chemoradiotherapy.
Combined modality chemoradiotherapy treatment may be considered a reasonable alternative in patients who are deemed medically unfit for cystectomy and for those who are seeking an alternative to radical cystectomy to avoid it’s dangerous complications (urinary diversion, erectile dysfunction, septic, urine or bowel leak, wound dehiscence, pulmonary embolus and hemorrhage).
The goals of BCT are to provide the survival equivalent of mastectomy and a cosmetically acceptable breast, with improved psychological health, self-esteem, sexuality, body image, quality of life. In BCT chemotherapy and radiotherapy used sequentialy.
STS involving either the upper or lower extremity, limb salvage can improve functional outcome and decreasing amputation after using of compined chemo radiotherapy.
CRT with cancer esophagus inferior to surgery in survival but superior in QOL measures.
Concomitant chemoradiotherapy (CT/RT) is the gold standard for advanced cervical carcinoma, but with frequent debates over treatment schedules and toxicity.