الفهرس 
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Abstract
Cerebrovascular disorder are among the top ten causes of death in children, with rates highest in the first 5 years of life and was increased in males compared with females, Multiple risk factors are often present in patients. As a result, complex etiological investigation are often necessary. The aim of the study was to estimate the frequency of factor V Leiden mutation among other risk factors in children with ischemic stroke.
The study was conducted on twenty child recruited from the Pediatric Neurology Clinic, Ain Shams University Hospital in the period from April 2010 to July 2011. The age of studied patients age ranged from 6 months to 14 years.
Our study showed that:
Patients, less than 1 year constituted about (30%), patient’s group (1-5) year was about (45%), and patient’s group above 5 year was (25%). Males represented (70%) of the total patients group.
Motor deficit was the most common presenting clinical manifestation in about (95%), cranial nerves affection observed in (55%), seizure founded in (40%), disturbed level of conscious was found in (35%), and headache was observed in (30%).
Congenital cyanotic heart disease is an important risk factors and observed in about (10%) of studied patients.
Recurrence of stroke is a very important finding, suggesting the need for follow up and present in about (5%).
Prothrombotic factors was founded in (10%) in the form of Protein S deficiency and other factors was negative (0%).
Factor V Leiden mutation was estimated in about (25%) and all had heterozygous mutation.
MRI showed cerebral infarction in about (70%), basal ganglia infarction present in (20%), encephalomalacia (5%), and free MRI in (5%).
Vascular disorders by MRA and MRV show that left middle cerebral artery occlusion observed in (35%), right middle cerebral artery occlusion founded in (20%), right internal carotid artery occlusion founded in (20%), left internal carotid artery occlusion founded in (15%), and left anterior cerebral artery founded in (10%).