الفهرس 
Definition and diagnosisOnly 14 pages are availabe for public view
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Abstract
Understanding sepsis has advanced tremendously in the past 15 years. During that time, important advances in the pathophysiology of sepsis have led directly to new effective therapies. Septic shock is known as tissue hypoperfusion that occurs due to septicemia from an invading organism leads to state of tissue hypoxia, multi organ failure and death from such conditions, cleared vision of its pathophysiology about the nature of causative organism either bacterial or fugal with or without viral element, also about the sequential cascade of the human immune system that defend against the invading organism focusing on the immune dysfunction that occur resulting in progression from septicemia to septic shock.
Septic shock treatment deals with some conditions that patients have persistant hypoperfusion despite the vassopressor support, here comes the role of corticosteroids in improving these patients by rising their blood pressure and if they are dependable on mechanical ventilators they can be weaned preventing their deterioration to ARDS that has high mortality index compared to other causes of mortality of septic shock.
Corticosteroids become important member in the treatment of septic shock by its high dose of methylprednisolone (200-500 mg\d) and its high dose (100-300)mg\d) of hydrocortisone. Low dose corticosteroids succeeded in improving the mortality and morbidity beside low adverse effects of corticosteroids that occur obviously with the high dise regimen giving powerful arm in the septic shock mangement arms, giving a better prognosis to patients with septic shock.