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Abstract Breast cancer is the most common type of cancer in women. The increased risk may be attributable to endocrine factors such as nulliparity or the use of menopause replacement therapy, strong family history, or a history of therapeutic thoracic radiation. Treatment of breast cancer requires multimodality treatment include surgery, radiotherapy, chemotherapy and hormonal treatment. Most author show a positive association between the presence of hormonal receptors and favorable prognosis for both disease free and overall survival. In our study we tried to find the correlation between quantitative estrogen and progesterone receptors with local recurrence, disease free (DFS), overall survival (OS) and type of distant metastasis. Here, we followed 412 patient files presented to Alexandria clinical oncology and nuclear medicine department during the period from January 2003 to December 2008 and all data available in the patients files was collected and included in the master table and subjected to statistical analysis. The results showed statistically significant relation between quantitative PR and local recurrence, while quantitative ER is statistically insignificant. The results also showed statistically significant relation between quantitative ER and PR with disease free (DFS), overall survival (OS) and distant metastasis. So, in a multi-variant analysis in this study, it was found that the quantitative hormonal receptor is not an independent prognostic factor. |