الفهرس 
IntroductionOnly 14 pages are availabe for public view
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Abstract
A number of new 5-nitroimidazole derivatives were synthesized and structural elucidation of the compounds was performed by IR, 1H-NMR and Mass spectroscopic data and elemental analyses results which all agreed with the assigned structures. Studies and resarches have shown, that derivatives of 5-nitroimidazole and its own nucleosides have biological activity against gram-negative and gram-positive bacteria, which infect humans and animals and its medical uses became act as a remedy against these types of bacteria, hence , synthesis of new compounds of these families wit the effectiveness of high biological and fewer side effects take our attention.
5- Nitroimidazole (170) was allowed to react with ethycholoroacetate in dry acetone and in the presence of anhydrous potassium carbonate to affored 1-ethoxycarbonylmethyl-5-nitroimidazole (171) in 88% yield. Treatment of 1- ethoxycarbonylemthyl-5 nitroimidazole(171) with hydrazine hydrate in absolute ethanol at reflux temperature gave the corresponding hydrazide ( 172 ) in 84% yield. 1- ( 5-Nitroimidazol-1-y1 ) acetic acid hydrazide ( 172 ) was allowed to react with L-(-)- arabinose, D-(+) – XYLOSE, D-(+) – mannose and D-(+)- glucose in and aq. Ethanolic solution with a catalytic amount of acetic acid, to afford the corresponding sugar N-acylhydrazones 178-182 in 74-78 % yields. Treatment of the 178-182 with acetic anhydride in pyridine at room temperature gave the corresponding per-O-acety1 derivatives 183-187 in 75-82 % yields. However , reaction of the sugar hydrazones 178-182 with acetic anhydride at 100o C gave the sugar-substitued 1,3,4- oxadiazoline derivative 188-192 in 74-81 % yield