الفهرس 
Testosterone and sex hormone binding globulinOnly 14 pages are availabe for public view
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Abstract
This study was conducted on 56 children and adolescents with T1DM recruited from Diabetes Clinic Children Hospital, Ain shams University. They were 36 females and 20 males with a mean age of 14.21±2.00 years.
Thirty eight healthy children & adolescents of their siblings were taken for comparative study. They were 18 females and 20 males with a mean age of 14.35±1.99 years.
Our results revealed that:
Patients and controls were well matching as regards age (P=0.14) and gender (P=0.08).
There was statistically no significant difference between diabetic patients and controls regarding height for age SDS (P=0.13) and weigh for height SDS (P= 0.27).
There was statistically non significant difference between diabetic patients and control as regards Tanner staging (P = 0.103).
There was statistically non significant difference between diabetic patients and controls regarding fasting insulin level (P= 0.021).
Female diabetic patients had a significantly more frequent menstrual irregularities (P=0.00038) and hirsutism (P=0.006) compared to controls, but there was statistically non significant difference as regards the age of menarche (P=0.47).
Male diabetic patients had a significant lower SHBG level compared to controls (P=0.05), but there was statistically non significant difference between diabetic female patients and female controls as regards SHBG level (P=0.42).
There was statistically a significant difference between male diabetic patients and controls as regards total testosterone level (P=0.001), but there was statistically no significant difference between diabetic female diabetic patients and controls as regards total testosterone level(P=0.098).
There was statistically a significant difference between male diabetic patients and controls as regards free testosterone level(P=0.0001), but there was statistically no significant difference between female diabetic patients and controls as regards free testosterone level(P=0.107).
The number of male subjects with high SHBG were higher in controls 16(80%) compared to patients 4(20%), while 14 patients (70%) had normal SHBG compared to 6 controls (30%) (P=0.0014).
The number of female subjects with high SHBG were higher in controls 16(88.9%) compared to patients 12(33.3%), while 24 patients (66.7%) had normal SHBG compared to 2 controls (11.1%) (P=0.0001).
Sixteen male diabetic patients (88%) had increased total testosterone level and 4 patients (20%) had normal level; meanwhile all controls had normal total testosterone level except of 4(20%) that had decreased level(P=0.000012).
Female diabetic patients had normal, increased and decreased level of total testosterone of 47.4%, 36.8% and 10.5% respectively, while 8 female controls (44.4%) had normal level and 10 (55.6%) had increased total testosterone level(P=0.243).
Sixteen male diabetic patients (88%) had increased free testosterone level and 4 patients (20%) had normal level; meanwhile all controls had normal free testosterone level except of 4(20%) that had decreased level(P=0.0001).
Female diabetic patients had normal, increased and decreased level of free testosterone of 47.4%, 36.8% and 10.5% respectively, while 8 female controls (44.4%) had normal level and 10 (55.6%) had increased free testosterone level(P=0.243).
Patients in group II (HbA1> 7.5) had significantly higher insulin dose (P=0.046) and higher fasting blood glucose (P=0.018) compared to patients in group I (HbA1c≤ 7.5).
Male patients in group II had significantly higher total and free testosterone levels (P=0.001) compared to patients in group I.
Female patients in group I had significantly higher SHBG (P=0.006) and free testosterone (P=0.005) compared to those in group II
In diabetic patients, SHBG was positively correlated with waist circumference, while it was negatively correlated with insulin dose, BMI and HbA1c. Total testosterone was positively correlated with age, age of onset, Tanner staging, presence of menstrual irregularities, HbA1c and waist circumference, while it was negatively correlated with BMI and HOMA-IR. Free testosterone was positively correlated with age, age of onset, Tanner staging, HbA1c and waist circumference, while it was negatively correlated with BMI and HOMA-IR.
In control siblings, SHBG was negatively correlated with presence of menstrual irregularities. Total testosterone was positively correlated with age and HOMA-IR. Free testosterone was positively correlated with age, presence of hirsutism and HOMA-IR.