الفهرس 
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Abstract
Hepatocellular carcinoma (HCC) is the sixth most common neoplasm, the third most frequent cause of cancer death and the leading cause of death
among patients with cirrhosis. In Egypt, HCC represent the fourth most
common cancer and its incidence had raised a three-fold in the last two
decades. The calculated total tumor volume was proposed to be a better
parameter to describe tumor burden in HCC patients as opposed to the
current standard of number and size of tumor nodules which may be a useful
tool for predicting prognosis in patients with HCC.
The main objective of this work was to study the role and the
prognostic accuracy of total tumor volume (TTV) in prediction of survival in
patients with hepatocellular carcinoma.
This was a retrospective study that based on reviewing of patients
records from hepatocellular carcinoma registry at National Liver Institute,
Menoufiya University from 2005 to 2012. The records included 725 patients
diagnosed as having hepatocellular carcinoma based on the finding of
typical radiological features in at least one contrast enhanced study or liver
biopsy if done with or without serum AFP level >400ng/ml.
The extracted data included:
Demographic criteria: Age, gender, occupation and smoking.
Clinical and laboratory parameters: Ascites, encephalopathy, serum
bilirubin, serum albumin, prothrombin time, INR, serum creatinine,
serum AFP, viral markers (HCV Ab and HBs Ag), performance
status, Child Pugh grade, MELD score, CLIP score and BCLC staging
system.