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العنوان
Synthesis And Antimicrobial Evaluation Of Novel Peptides And Sugars Hydrazone Attached To C-Furyl Glycoside /
المؤلف
.Raslan, Heba Abo-Elsoud
هيئة الاعداد
باحث / Heba Abo-Elsoud Raslan
مشرف / Adel Abdel-Hady Nassar
مناقش / Adel Abdel-Hady Nassar
مشرف / Ahmed El-Sayed Abdel Megied
الموضوع
Chemistry. Glycosyl halides. Chemistry, Organic
تاريخ النشر
2013 .
عدد الصفحات
126 P. :
اللغة
الإنجليزية
الدرجة
ماجستير
التخصص
Organic Chemistry
تاريخ الإجازة
1/7/2013
مكان الإجازة
جامعة المنوفية - كلية العلوم - Chemistry Department.
الفهرس
Only 14 pages are availabe for public view

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from 126

Abstract

Synthesis and antimicrobial evaluation of some sugar hydrazones and schiff bases attached to C-furyl glycosides In this investigation, when 3-carbohydrazide-5-C-(l,4-anhydro-β-D-erythro-tetrofuranosyl)-2-methylfuran (90) was allowed to react with the repective monosaccharides [D-(-)-ribose, D-(+)-xylose, D-(-)-arabinose, D-(+)-glucose, D-(+)-mannose, or D-(+)-galactose] in an aqueous ethanolic solution and a catalytic amount of glacial acetic acid gave the corresponding hydrazinosugar derivatives 98-103 in 70-77% yields, respectively. Synthesis and Antimicrobial Evaluation of α-Amino Acid Ester Bearing a C-Furyl Glycoside Side Chain Treatment of 90 at -5oC in AcOH and 1N HCl with NaNO2 afforded the inseparable azide derivative.The yellow syrupy azide compound was then treated, in situ, with the appropriate amino acid ethyl esters in ethyl acetate containing Et3N at 0oC to give, after neutralization, the desired glycopeptides 122-126 in 75- 80% yields