الفهرس 
INTRODUCTIONOnly 14 pages are availabe for public view
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Abstract
The genotoxic effect is one of the serious risks results from the
use of pharmaceuticals and result in genetic damage. The induction
of genetic damage is a critical step in the production of different
genetic diseases in future generations, birth defects and contributes
to somatic diseases such as cancer in the present generation.
Therefore it is necessary to evaluate the genotoxic potential of drugs
to evaluate their ability to cause cancer and other defects.
The genotoxic effect of the two antibiotics (ciprofloxacin and
rifampicin) administration and their combination with curcumin
treatment in male mice to ameliorate the ciprofloxacin and
rifampicin -induced genotoxic effects was investigated through
determination of the DNA damaging effect,the serum level of 8-
hydroxy-2’-deoxyguanosine(8-0HdG),comet assay and the gene expression of certain enzymes( Glutathione s-transferase u2, Glutathione s-transferase mu 2, catalase, Cytochrome P450 2El, 8- oxoguanine DNA glycosylase 1) in liver tissues. In the present study 80 Male white Swiss mice aged 9-12 weeks were used. The animals were obtained from the Central
Animal House, Faculty of Veterinary Medicine, Zagazig University.
They were maintained on basal ration and tap water and
photoperiod 12L/12D cycle.
Mice were kept at a constant environmental and nutritional
condition throughout the periods of the experiment.