الفهرس 
Natriuretic PeptidesOnly 14 pages are availabe for public view
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Abstract
B-type natriuretic peptide (BNP) has diagnostic and prognostic value in a wide variety
of cardiac disorders including heart failure and acute coronary syndromes (ACS), however it is value
in Percutaneous Coronary Intervention (PCI) is not well established.
Objective: We aimed to assessed whether high level of BNP immediately after successful
Percutaneous Coronary Intervention (PCI) was associated with Major Adverse Cardiac Events
(MACE) during hospitalization ( as recurrent chest pain, new or worsening heart failure, significant
arrhythmia and in-hospital mortality ) and after 3 months follow up ( as rest chest pain,
hospitalization for ACS or heart failure, revascularization and cardiac mortality ).
Methods: In 88 consecutive patients with ACS, plasma BNP levels were measured immediately
after successful PCI . Patients were followed for 3 months for the occurrences of MACE. The
patients were divided into 2 groups according to occurrence of composite end points of MACE at
follow-up; MACE (-) Group: 65 patients who did not have MACE and MACE (+) Group: 23
patients who had MACE.
Results: During hospitalization, MACE occurred in 15 patients. During the follow up, MACE
occurred in 23 patients ( MACE (+) Group ). A statistically significant positive correlation between
BNP levels and age (r = 0.261; p = 0.014), diabetes mellitus (r = 0.271; p = 0.011), hypertension (r =
0.264; p = 0.013), serum creatinine (r = 0.268; p = 0.012), occurrence of new or worsening heart
failure (r = 0.249; p = 0.019), composite end points of in hospital MACE (r = 0.233; p = 0.029) and
composite end points of MACE at follow-up (r = 0.276; p = 0.009) were identified. The plasma BNP
levels in MACE (+) group were significantly higher than that of MACE (-) group [1330 ± 167 vs.
1176 ± 273 pg/ml ; p = 0.01]. Multiple logistic regression analysis identified the BNP (OR 1.003,
95% CI 1.000-1.005, p = 0.045) as independent predictors of MACE during the 3 months follow up
period.
Conclusion: High levels of plasma BNP collected immediately after successful PCI in patients with
ACS are associated significantly with MACE during hospitalization and 3 months follow up. The
plasma BNP is an independent predictors of MACE during the 3 months follow up period.