الفهرس 
COVEROnly 14 pages are availabe for public view
 |  | from | 168 |  |  |
| | | from | 168 | | |
Abstract
The world-wide problem of abnormal QTc is not sufficiently evaluated in our country. In recent years, several syndromes potentially responsible for arrhythmic sudden death have been described. Most of them have been primarily identified from abnormal baseline ECG patterns in patients with aborted sudden cardiac death and their relatives.
The aim of this study was to establish normal values for QT interval in Egyptian newborns and compare the corrected QT interval in normal Egyptian neonates to published values for other ethnic groups.
One hundred neonates with ages ranging from 8 days to 28 days with a mean age of (12.6 ± 4.2) days were enrolled in this study, coming for follow up in NICU of Ain Shams University Children’s Hospital.
This cross sectional study was performed during the period from 1/2/2010 to 15/8/2010. An informed consent was obtained from the parents or care-givers prior to enrollment.
All neonates in the study were subjected to history taking from mothers, thorough clinical examination, 12 lead ECG recording using (Fukoda denshi machine) laying stress on QTc interval assessment using Bazett’s formula, M mode,2D, Colour Doppler, pulsed and continuous doppler echocardiographic study as well as laboratory investigations that included CBC, liver and renal functions.
53% of the studied neonates were males and 47% were females with no significant correlation between sex and QTc
9% of studied neonates were found to have long QTc (>0.450 ms), 77 % of them were from Upper Egypt (60% of them were male and 40% were female), born to non consanguineous parents, to mothers who took no medications during pregnancy.
6% of the studied neonates had short QTc (<0.300 ms), 83% of them were from Delta (48% were males and 52% were females) born to non consanguineous parents, to mothers who took no medications during pregnancy.
No significant difference was found between QTc and post natal age. A significant +ve correlation was found between QTc and Systolic blood pressure.
No statistically significant correlation was found between QT interval and diastolic blood pressure, P wave duration, P wave amplitude, PR interval duration, ST segment duration, T wave duration and T wave amplitude.
In our results the cut off value of long QTc (>0.44 ms) and the cut off value of short QTc (<0.29 ms) and the normal range of QTc between 0.290 ms and 0.440 ms.
A statistically significant difference was found between Upper Egypt & Delta regarding long and short QTc distribution, 77% of patients with long QTc were from Upper Egypt versus 33% from Delta while 83% of patients with short QTc were from Delta versus 17% from Upper Egypt.