الفهرس | Only 14 pages are availabe for public view |
Abstract This study was done in order to evaluate the levels of plasma ionized magnesium in neonatal jaundice and correlate them with the levels of serum bilirubin. Our study included 60 full term newbornsofappropriate gestational age admitted at El Minia Pediatric University Hospital. The cases included in the study were divided into two groups: Group I (hyperbilirubinemia group) includes 40 newborn infants with jaundiceand group II (control group) includes 20 newborn infants without jaundice. The studied groups includednewborn infants with neonatal jaundice, appeared during the period from the 3rd to the 5th day of life. The present study revealed that: •There was a significant increase in the plasma ionized magnesium in the hyperbilirubinemia group when compared to control group. •There was a positive correlation between plasma ionized magnesium and serum bilirubin. Conclusion The results of the study suggest that increased levels of plasma ionized magnesium in hyperbilirubiemia casesmight be due to extracellular movement of Mg, a principally intracellular ion, resulting from bilirubin-induced generalized cellular injury including neurons and erythrocytes. Consideringneuroprotective functions and beneficial effects of Mg ion in improving neurologic outcome, we also may speculate the possibility of a neuroprotective role or a compensatory mechanism of increased IMg levels to reduce bilirubin toxicity. |