الفهرس 
INTRODUCTIONOnly 14 pages are availabe for public view
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Abstract
Carnitine is a hydrophilic natural substance acquired mostly through dietary meats and dairy products and is used by cells to transport hydrophobic fatty acids.The carnitine shuttle is responsible for transferring long-chain fatty acid across the barrier of the inner mitochondrial membrane to gain access to the enzymes of beta-oxidation. The oxidation of fatty acids is an important source of energy for ATP production In mitochondrial through the entery of acetyl-CoA into the Kerbs. cycle. The carnitine shuttle consists of three enzymes: carnitine palmitoyltransferase I (CPTIA and CPTIB), carnitine acylcarnitine translocase (CACT), carnitine palmitoyltransferase 11 (CPTII) and smallsoluble molecule, carnitine to transport fatty acids as their long-chain fatty acylcarnitine esters.
Mitochondrial dysfunction is increasingly implicated in the etiology of drug-induced toxicities. Mitochondria can be damaged both directly and indirectly by medications. Some antibiotics inhibit mitochondrial beta-
oxidation enzymes. The aim of this study to evaluate the possible effects of some antibiotics
on carnitine shuttle. For this purpose three groups of rats (thirty rats for each) were used and assembled as follow: Group I ( control group ): 30 rats of this group were injected with normal saline subcutaneously (S.C) once daily (10 rats for 2 days, 10 rats for days and 10 rats for 6 days).