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Abstract Pancreatitis is an inflammatory disorder of the pancreas which occurs with an estimated incidence of 10-40 per 100 000 per year in the UK. Mild acute (oedematous or interstitial) pancreatitis accounts for 80% of cases, is self-limiting, and usually resolves with simple supportive management in 3-5 days. Severe acute pancreatitis (SAP) accounts for the remainder of cases and was defined by the Atlanta Symposium as acute pancreatitis associated with organ dysfunction or local or regional complications. Most deaths from SAP result from sepsis and multiorgan failure. Mortality in patients with infected pancreatic necrosis is 25-30%, compared with 10-12% in those with sterile necrosis (Simon et al., 2008 |