الفهرس 
Acne Scars: Pathogenesis and ClassificationOnly 14 pages are availabe for public view
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Abstract
Acne vulgaris is a common almost physiologic
skin condition that is likely to affect up to 80% of
people between the age of 11 to 30 years. A
significant proportion may eventually result in scarring
that is usually related to the severity of preceding
inflammation, stage and nature of treatment, nature of
local manipulation, as well as individual predisposition
to scarring.
Several techniques have been suggested for
the treatment of acne scars that vary in nature and
reported efficacy according to the type and severity of
the treated scar. These include surgical techniques
e.g. dermabrasion, microdermabrasion, punch
excision, punch grafting, punch elevation, and
subcision, as well as non-surgical techniques e.g.
radiofrequency fillers, peeling, laser (ablative or nonablative),
plasma skin regeneration, and intense
pulsed light.In this study we tried to asses to assess the use
of whole plasma or the so called platelet-poor plasma
as a natural filler in treatment of superficial atrophic
distensible post acne scars
In this study, 32 patients suffering from
superficial distensible post acne scars of the face
were divided into 4 groups (with 8 patients in each
group):
group AI: Patients were treated by injecting PPP
only.
group AII: Patients were treated by injecting PPP
followed by Dermaheal HSR® (Lamelle research
laboratories. Korea)
group BI : Patients were treated by injecting PPP
followed by oral intake of (KapronR) tablets.
group BII: Patients were treated by injecting PPP
followed by Dermaheal HSR® injection, followed
by oral intake of (KapronR) tablets. In all groups, patients received 3 sessions with a
2 week-interval between sessions and follow up was
done after 12 weeks.
The study could show that all the four groups
showed significant improvement but with some
variation in the percentage of the improvement
between the groups. After the follow up period, group
BII showed the best results with an average
improvement of 46% (± 0.170), this was followed by
group AII with an average improvement of 40% (±
0.185) then group BI with an average improvement of
25% (± 0.258) and lastly group AI with an average
improvement of 22% (± 0.194).
It was also noticed that in all the 4 groups, the
greatest degree of improvement was observed after
the first session followed by less noticeable
improvement after each session. After completing the
sessions and during the follow up period, a certain
degree of regression was noticed in all groups.
So, in view of the present study, PPP injection
seems promising as an easy and cheap technique to correct such filling defects as scars and wrinkles at
least as an ancillary line of treatment. Nevertheless,
many variables in the technique are yet to be
standardized for optimum efficacy.
To get better results, the technique may be
supplemented by local injection of an appropriate
fibroblast stimulating agent(s) +/- additional
administration of an appropriate antifibrinolytic agent.
Further evaluation and more prerequisites are
needed before firm conclusions can be made about
that technique. These include trial on a larger number
of patients, long term follow up as well as
histopathologic examination of the injected sites to
document the histopathological changes that took
place at the injected sites.