الفهرس 
Systemic Lupus ErythematosusOnly 14 pages are availabe for public view
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Abstract
, Systemic lupus erythematosus (SLE) is an autoimmune disorder that j affects multiple organs and is characterized by production of autoantibodies and immune complex deposition in various organs, leading to intlammation and tissue destruction, The onset of SLE is usually after puberty, typically in the twenties and thirties .. SLE is much more common in women than men 9: I ), with peak onset during childbearing years. The course of the disease is marked by episodes of active inflammation and clinically silent remission. No single cause has been identified and SLE has a complex genetic basis.Although the definite etiopathogenesis of SLE remains unclear, many different mechanisms may contribute to the pathogenesis ofSLE. Several studies have established that Th 17 cells are essential for the propagation of the immune response in preclinical models of autoirnmunc diseases and recent studies have implicated Th 17 in the pathogenesis of SLE.IL-23 plays a role in the ditferentiation of Thl7 from naive T cells, and it is appears to be essential to expand and maintain Th 17 cells. Sera IL-23 and I L- 17 levels and the number of Th17 cells have been reported to be elevated in SLE patients compared to control subjects.