الفهرس 
COVEROnly 14 pages are availabe for public view
 |  | from | 141 |  |  |
| | | from | 141 | | |
Abstract
Polycystic ovary syndrome (PCOS) is a common endocrinologic disorder in women, characterized by chronic anovulation, hyperprolactinaemia and infertility (Kucuk and Kilic-Okman, 2005).
In 75% of patients with PCOS, ovulation induction occurs with clomiphene citrate (CC) treatment however 25% of patients are clomiphene citrate resistant and require alternative treatment (Palomba et al., 2006).
The aim of this study was to evaluate the changes in the serum prolactin level after LOD in patients with PCOS who still not responding to the drilling.
One hundred patients with PCOS were selected from the infertility clinic of Ain Shams University Hospital, where LOD was done for them during the period from September 2009 to June 2010.
All these women were infertile due to anovulation because of PCOS and all other causes of infertility were excluded.
According to the expert meeting in Rotterdam (2003), PCOS was diagnosed when at least two of the following three criteria were present: (1) oligo-ovulation or anovulation, (2) clinical and/or biochemical signs of hyperandrogenism, or (3) polycystic ovaries on u/s.
All selected participants were CC resistant (ovulation did not occur after 3-4 cycles of CC treatment at the maximum dosage 250 mg/day for 5 days from the second or third day of the menstrual cycle) (Palomba et al., 2006).
The patients’ age ranged between 20-35 years (mean 27.73 ± 4.506); 61 of them had primary infertility and 39 had secondary infertility.
The procedure was performed by triple puncture technique using Storz laparoscopy equipment. Cauterization was done by unipolar electrode at 4 points with the diathermy probe setting at 40 watts for 4 seconds at each point.
All patient were euprolactinemic before LOD (mean 11.218 ± 4.83). 34% of the participant were still not responding to LOD, there was significant increase in serum PRL (mean 19.98 ± 10.46) after three months of LOD.
The participants who remained anovulatory showed significantly higher mean BMI (26.83 ± 2.57) when compared to ovulatory participants (25.74 ± 2.4).
No correlation of pre and post LOD prolactin with age, FSH, type and duration of infertility levels in non-ovulating patients.