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Abstract For all patients the following were done: Thorough history, general and abdominal examination, CBC, FBS, serum Creatinine, ALT,AST, albumin, bilirubin, P.C ,HCVAb, HBsAg, Anti–shistosomalAb and quantitative PCR for HCV. Ultrasound was done for all patients and splenic volume was measured for all patients. In our study the sample was homogenous and our groups were matching so, there was no statistically significant difference between group Ia (+ve PCR before treatment) and group Ib (+ve PCR nonresponders) regarding the demographic factors. We found that, there was high statistically significant difference between group Ia and control group regarding splenic volume (mean splenic volumes were 174.31 and 157.29 respectively). That means that the group Ia have a higher splenic volume than the normal. Also we found that, there is significant positive relationship between splenic volume and HCV RNA level in group Ia which means that the splenic volume increase as the HCV RNA concentration by PCR increase. ( Key words : The relation between HCV viraemia and splenic volume in chronic HCV infected patients |