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Abstract Idiopathic pulmonary fibrosis (IPF) is defined as a specific form of chronic fibrosing interstitial pneumonia limited to the lung, with the histopathology of usual interstitial pneumonia (UIP) on surgical (thoracoscopic or open) lung biopsy (ATS/ERS, 2000). Pathological angiogenesis is associated with all chronic inflammatory and chronic fibroproliferative disorders as well as with tumor growth. The terms angiogenesis and vascular remodeling are often used interchangeably in the context of both pathological and aberrant angiogenesis (Polverini et al., 2002). |