الفهرس 
Uremic milieu in chronickidney diseaseOnly 14 pages are availabe for public view
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Abstract
Background: Cardiovascular disease is an important cause of morbidity
and mortality in patients undergoing maintenance dialysis. There is
evidence supporting a direct role for the uremic milieu, and an indirect role
as well, for enhanced cardiovascular complications. On-line dialysis
modalities, such as on-line hemodiafiltration, raise particular concerns
because not only small molecules are removed more effectively as
compared to low-flux hemodialysis, but in addition, a considerable
clearance of so-called middle molecular weight (MMW) substances is
obtained including those involved in cardiovascular morbidities.
Objectives: To assess the effect of on-line hemodiafiltration on removal of
uremic toxins that cannot be removed during conventional hemodialysis,
e.g. homocysteine, and improving the chronic inflammatory state
associated with chronic kidney disease and the possible impact of these
changes on myocardial function in chronic hemodialysis patients.
Methods: In this study, we compared different clinical, lab and radiological
data of 30 chronic hemodialysis pediatric patients on low-flux hemodialysis
with the same data after 6 months of initiation of predilution on-line
hemodiafiltration to clarify the possible impact of on-line hemodiafiltration
on cardiovascular system in those patients.
Key words: On-line hemodiafiltration, homocysteine, cardiovascular
morbidities, chronic inflammatory state