الفهرس 
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Abstract
DBP is a class of man-made chemicals widely used to soften br plastics, act as adhesives or solvents and hold color and personal care br products. Also can be found in paints, flooring, wall covering, carpets, br glues, printing inks, insect repellents, hair spray, shampoo, nail polish, br cosmetics, medical intravenous bags and tubing. br Therefore, the present work was designed to study the testicular br toxic effect of DBP in the developing and adult albino rats and the br possible protective role of curcumin biochemically, histologically, br immunohistochemically and morphometrically. br 72 adult albino rats were used in this study and were classified br into two groups: br Group I: consisted of 35 pregnant rats, they were subdivided br into three groups; Group IA: that was further subdivided into negative br control, curcumin and corn oil subgroups, Group IB (DBP group) and br Group IC (combined DBP and curcumin). The male pups were br sacrified one day, two, four and six weeks after birth. br Group II: consisted of 30 adult male albino rats, they were br subdivided into four groups; Group IIA: that was further subdivided br into negative control, curcumin and corn oil subgroups, Group IIB br (DBP group), Group IIC (combined DBP and curcumin) and Group br IID (recovery group). br At the time of sacrifaction, blood samples were collected via the br tail vein and subjected to the biochemical study (measuring level of br TH), the testicular specimens were collected and subjected to br histological, immunohistochemical study using Hx. - E., MGP, PAS br stains, immunostaining using Caspase 3 and PCNA stains and br 205 br Summary, Conclusion - Recommendations br morphometrical study of the mean diameter of the seminiferous br tubules and the intensity of Caspase 3 immunostain in the germ cells br of the testis. br The results obtained could be summarized as follows: br In the control groups, the testis showed the normal testicular br structure in developing and adult rats. br In group IB; the biochemical findings of the mean serum TH br level showed highly significant decrease as compared to subgroup IAa br - group IC in one day, two and six weeks old rats and significant br decrease in four weeks old rats. br The histological findings of different ages stained with Hx. - br E. stain, showed loss of stratification and disorganization of the lining br epithelium of the seminiferous tubules. Some germ cells appeared br exfoliated in lumen and detached -#102;-#114;-#111;-#109; the basement membrane with br increased number of the gonocytes in the one day old rats only, br disappearance of the early spermatids in the four weeks old rats, br disappearance of the late spermatids and appearance of apoptotic br bodies in the six weeks old rats. The seminiferous tubules were br surrounded by disrupted basal lamina and separated by wide br interfollicular spaces in which the interstitial tissue appeared br distructed and contained dilated congested blood vessel, vacuolation, br hyalinized material and the interstitial Leydig cells showed br hyperplasia and clustering in some tubules. The testicular capsule was br thickened and the tunica vasculosa contained dilated congested blood br vessels in all ages. br Examination of the testes of rats received DBP (group IB - br IIB) stained with MGP showed mild DNA reaction in the nuclei of the br germinal epithelium and low content of RNA in their cytoplasm.