الفهرس 
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Abstract
Nephrotic syndrome (NS) is a common chronic disorder,
characterized by alterations of permeability at the glomerular capillary
wall, resulting in its inability to restrict the urinary loss of protein.
Leptin is a 16-kDa polypeptide hormone that is mainly, but not
exclusively, produced in adipose tissue and plays a key satiety role in
regulating food intake and energy expenditure.
The kidneys play a key role in the systemic elimination of
circulating leptin. Leptin is not metabolized by the kidney but is excreted
as an intact protein.
The purpose of this study that included 80 children (60 children
with nephrotic syndrome and 20 healthy children as a control group) was
to study the changes in serum and urine leptin concentrations in children
with nephrotic syndrome during relapse and remission and to find out
whether those children have proportionate changes in serum and urine
leptin levels to known disturbances in lipid metabolism.
The present study revealed that in children with nephrotic
syndrome the increased leptin loss in the urine was accompanied by a
decrease in its serum levels and there was a positive linear correlation
between leptin and albumin levels in the serum and between leptin and
protein levels in the urine.
In our results we found that serum cholesterol and serum
triglycerides were significantly higher among patients with
nephrotic syndrome compared to controls and were significantly