الفهرس 
DIABETES MELLITUSOnly 14 pages are availabe for public view
 |  | from | 298 |  |  |
| | | from | 298 | | |
Abstract
Background: Diabetes complications represent a huge burden for patient and health services. Cardiomyopathy remains a major source of morbidity and mortality. Myeloperoxidase (MPO) (a hemoprotein that is abundantly expressed in polymorphonuclear leukocytes) is believed to be one of the most promising cardiac markers. It predicts the early risk of myocardial affection.
Aim of the study: this study examined plasma myeloperoxidase as a marker of oxidative stress in diabetic children and adolescents and its relation to myocardial performance for early detection of cardiac affection in these patients.
Methodology: one year cross sectional study on 50 diabetic children (type 1 DM) from Pediatric Diabetic Clinic, Ain Shams University. All patients subjected to full history taking, laboratory investegations (CBC, lipid profile, Microalbuminuria, HbA1C & plasma Myeloperxidase) and Doppler and tissue doppler echocardiography.
Results: Results showed that Plasma Myeloperxidase was significantly higher in diabetics compared to controls. MPO levels increased with microalbuminuria. Positive correlation was found between myeloperoxidase and left ventricular posterior wall thickness( LVPWT) in diabetic patients. Diastolic dysfunction is proved in our studied diabetics by doppler and tissue Doppler. Tei index, LVPWT, E/A and E”/A” were correlated with duration of diabetes and HbA1c. MPO had a prediction value for LV Tei tissue index affection with a sensitivity 80.43% & specificity 77.78% (AUC = 0.829, best cut of point <36) which was statistically significant (<0.0001).
Conclusion: Although, no significant correlation was found between myeloperoxidase and indices of systolic and diastolic dysfunction in diabetic patients, Plasma MPO concentrations provide a good prognostic value for the prediction of myocardial performance index for detection of cardiac affection in diabetic children, proving that Doppler and tissue Doppler has the upper hand especially tissue Doppler.