الفهرس 
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Abstract
Background: One of Multiple sclerosis (MS) presumed pathological
mechanisms is failure of apoptosis of autoreactive T lymphocytes.
Objectives: To determine the relationship between tumor necrosis factorrelated
apoptosis-inducing ligand (TRAIL) mRNA gene expression ratio
and serum TRAIL levels with MS susceptibility and brain atrophy.
Materials and methods: This study was conducted on 53 relapsing
remitting MS patients and 25 matched healthy volunteers. The expression
of TRAIL on peripheral blood lymphocytes was analyzed by RT-PCR,
serum levels of soluble TRAIL (sTRAIL) was determined by ELISA and
MRI brain for measurement of black holes and the bicaudate ratio (BCR)
as a measure of brain atrophy were done for all patients. Results: The
sTRAIL level was lower in MS patients compared to the control but no
difference was found in the TRAIL mRNA gene expression ratio. A
positive correlation was found between EDSS and age of patients while a
negative correlation was found between progression index and both disease
duration and BCR. Conclusion: Apoptosis of T lymphocytes is deficient in
MS patients which can be implicated in the treatment. No difference
between TRAIL mRNA gene expression ratio between MS patients and
controls.
Keywords:
Multiple sclerosis, Apoptosis, Tumor necrosis factor related
apoptosis inducing ligand (TRAIL), TRAIL mRNA gene expression,
Bicaudate ratio.