الفهرس 
Review Of The LiteratureOnly 14 pages are availabe for public view
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Abstract
Rheumatoid arthritis (RA) is an autoimmune disease that causes chronic inflammation of the joints. Rheumatoid arthritis can also cause inflammation of the tissue around the joints, as well as in other organs in the body. It is chronic illness that last for years without symptoms .
The aim of this study is to assess serum level of anti CCP and COMP in patient with rheumatoid arthritis and its relation to disease activity. and to compare serum level of anti CCP with serum level of rheumatic factor in diagnosis of rheumatoid arthritis, also to Compare serum level of COMP in rheumatoid arthritis patient with serum level of COMP in patient with other autoimmune inflammatory
This study was done during the period from april 2011to February 2012 on 80 patients, 60 patients from those attending the outpatient clinic and impatient of Rheumatology Department in Benha University Hospital,54females and 6 males .Their ages ranged from 35-55 years and,20 apparently healthy subjects as a control group(17 females,3males) The ages of the control group ranged between 35-45 years the studied individual were divided into 4 groups. Group1: It consisted of 20 individual with established rheumatoid arthritis Group2: It consisted of 20 individual highly suspected (sero negative ,rheumatoid factor negative) Group3: : It consisted of 20 individuals with diagnosed other autoimmune inflammatory disease Group4: (control group) It consisted of 20 individuals with matched age and sex
All patients underwent complete history taking, general and complete
rheumatological examination. Also laboratory investigation was done which
Summary
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included ( CBC, ESR, CRP, , IgM RF and antiCCP,COMP).In addition, disease activity evaluation was done using the disease activity score(DAS)
The results of this study revealed that:
There was no significant relation between anti-CCP antibody levels and either the patients‘ age .sex or HB However, there was a significant relation between anti-CCP levels and either morning stiffness, Family history of RA, Swelling, Limited movement, ESR levels
There is significant relation between serum level of anti CCP antibodies and serum level of RF among the studied groups
There is significant relation between serum level of anti CCP antibodies and serum level of COMP among the studied groups
There were Significant relation between serum level of anti CCP antibodies and DAS(group1,2)
There is significant relation between serum level of anti CCP antibodies and cartilage destruction among the studied groups(group1,2)
There was no significant relation between COMP and either the patients‘ age .sex family history of RA or HB However, there was a significant relation between COMP and either morning stiffness, , Swelling, Limited movement, ESR levels
There is significant relation between serum level of COMP and serum level of RF among the studied groups
There were significant relation between serum level of COMP and DAS (group1,2)
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There were significant relation between serum level of COMP and cartilage destruction among the studied groups (group1,2)
There was no significant relation between RF and the patients‘ age .sex or HB However, there was a significant relation between RF and either morning stiffness, family history of RA , Swelling, Limited movement, ESR levels.
There were significant relation between serum level of RF and DAS(group1,2)
There is significant differance between serum level of COMP in RA patients and patients with other autoimmune disease
In our study the Sensitivity of anti ccp in diagnosis of RA was77.5% and the specifity was 73.3% however the Sensitivity of RF in diagnosis of RA was 50% and the specifity.