الفهرس 
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Abstract
Introduction. Recent evidence suggests that helicobacter pylori
infections play a role in the pathogenesis of a variety of skin diseases.
Various mechanisms have been proposed in an attempt to explain the
extra intestinal manifestations of H. pylori infections. They are based
on the ability of H. pylori to initiate systemic immune response whether
humoral or T cell mediated. Vitiligo is a generalized depigmented
disorder manifesting as acquired white patches due to loss of
melanocytes. Immune dysregulation play an important role in the
pathogenesis of vitiligo. So, we may propose that H. pylori may play a
role in vitiligo through triggering an immune response. Aim of the
Work. To clarify if helicobacter pylori plays a role in the pathogenesis of
vitiligo or not. Patients and methods. The study included 40 patients
with different types of vitiligo without GIT symptoms as well as 40
healthy volunteers served as control. Anti Helicobacter pylori Igs (IgG,
IgA, IgM) was assessed in the serum of vitiligo patients and controls
using ELISA Test. Results. An overall anti H. pylori IgG antibody
seropositivity of 57.5% (n = 23) was found in vitiligo patients compared
with an overall value of 30% (n = 12) for the control group. The
difference in seropositivity between patients and controls was statistically
significant (P-value = 0.013). An overall anti H. pylori IgA antibody
seropositivity of 32.5% (n = 13) was found in vitiligo patients compared
with an overall value of 15% (n = 6) for the control group. The difference
in seropositivity between patients and controls was not statistically
significant (P-value = 0.066). Anti H. pylori IgM antibody seroprevalence
of the vitiligo patients and controls was negative. When comparing the
IgG level in the patient and control groups, the mean expression level of
IgG in the serum of vitiligo patients was higher than in the control serum,
and this difference is statistically significant (P Value = 0.041). While
the mean expression level of IgA, IgM in the serum of vitiligo patients
was higher than in control group but this difference is statistically not
significant (P-value= 0.060, 0.580 for IgA, IgM respectively).
Conclusion. Increased prevalence of H. pylori infection in association
with vitiligo, together with the high level of anti H. pylori IgG in vitiligo
patients compared to control are with our concept that H. pylori infection
may play a role in the pathogenesis of vitiligo.
Keywords. H. pylori, vitiligo, ELISA Test, Anti Helicobacter pylori Igs.