الفهرس 
InfertilityOnly 14 pages are availabe for public view
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Abstract
Infertility is a common gynecological problem that has a multifactorial etiology. Chlamydia Trachomatis is one of the most common factor in a symptomatic and subclinical pelvic inflammatory disease (PID). The most important sequelae of PID is the occurrence of infertility resulting from occlusion or dysfunction of fallopian tube by post inflammatory fibrosis.
The risk of infertility post Chlamydial salpingitis is unknown, although a correlation between tubal infertility and the prevalence of antibody to Chlamydia Trachomatis has been noted.
Chlamydia are obligatory intracellular parasites and respond to some antibiotics. They differ from bacteria and virus, these structures contain DNA and RNA and have a rigid cell wall which cannot be cultured on artificial media and multiply by binary fission.
Chlamydial infection of epithelial cells at mucosal surface produces proinflammatory factors such as IL-8, which can lead to an acute inflammatory response characterized by neutrophil infiltration to the primary sites of infection, followed by a subepithelial accumulation of mononuclear leukocytes during the chronic phase of infection. These cellular responses promote cellular proliferation and tissue damage of affected organs. Most of the invasive bacterial pathogens often induce rapid but transient responses. In contrast C. trachomatis infection induces delayed proinflammatory responses especially IL-8 production in epithelial cells and is dependent on bacterial replication.
The most common anatomical site infected with Chlamydia trachomatis is the endocervix and then spread to infect the endometrium and tubes.
Diagnosis of Chlamydia trachomatis can be carried out serologically by Enzyme-Linked Immunosorbent Assay (ELISA) microimmunofluorescence (MIF) or radioimmunoassay (RIA).
In this study, we investigate Chlamydia trachomatis and IL-8 serologically and in swab of endocervix by Enzyme-Linked Immunosorbent Assay (ELISA) in infertile women due to tubal factor.
The results suggested that no significant correlation between IL-8 and Chlamydial IgG in diagnosis of Chlamydia trachomatis infection.
So IL-8 can’t be used alone in determining which women infected with Chlamydia trachomatis.
Thus, we recommend that use of IL-8 for diagnosis of Chlamydial infection need more investigations and research.
The current recommended treatments for genital tract infections caused by C. trachomatis are azithromycin or doxycycline. Azithromycin is considered more effective because of it being a single 1-g dose compared to a 7-day course of doxycycline.