الفهرس 
Striae Distensae: OverviewOnly 14 pages are availabe for public view
 |  | from | 145 |  |  |
| | | from | 145 | | |
Abstract
Striae distensae are a well-recognized common disfiguring
skin condition that rarely cause a significant medical problem
but they have psychosocial consequences and are often a source
of significant distress to those affected.
They are predominantly located on the arms, thighs,
abdomen and lumbosacral area, causes of striae are not clear;
many authors had shown that the mechanical effect of
stretching is the main cause, leading to rupture of the
connective tissue framework as in pregnancy, obesity and
weight lifting. Others suggested that SD are features of high
serum levels of steroid hormones induced from local or
systemic steroid therapy or Cushing’s syndrome.
Histological studies revealed presence of initial
inflammatory changes followed by flattening and thinning of
the epidermis due to underlying changes in the numbers and
organization of collagen in recent striae. The pathogenesis
striae distensae is still unknown, but probably relates to changes
in the structures that provide skin with its tensile strength and
elasticity, some hormones such as estrogen, androgen,
glucocorticoids and relaxin were thought to be involved in
pathogenesis of SD by their effect on those structures. Our study was conducted on 30 female subjects aiming at
studying the expression of estrogen, androgen and glucocorticoid
receptors immunohistochemically in multigravida (MG) and
nulligravida (NG) having striae rubra and comparing the results to
skin of controls without SD.
Statistical analysis of immunohistochemical results
revealed that ERβ expression in the epidermis and dermis of
both lesional and non lesional skin of striae in MG and NG are
significantly lower than control group. Moreover, in both MG
and NG the lesional epidermis showed significant lower ERβ
expression in compare with non lesional epidermis, with no
significant change between lesional and non lesional in the
dermis.
On studying AR expression, there was a significant higher
AR expression in the epidermis of lesional skin of MG more
than NG and control. Epidermis of lesional area of MG showed
a significant increase in AR in comparison to non lesional
epidermis. NG showed significant increase in AR in both
epidermis and dermis in lesional areas in compared with non
lesional area in but significantly less than MG.