الفهرس | Only 14 pages are availabe for public view |
Abstract Allergic asthma is classified as a type 1 hypersensitivity reaction. This involves allergen-specific immunoglobulins of the IgE class bound to high-affinity Fcε receptors on the surfaces of basophils and mast cells present in the subepithelial layer of the airways. The airway hypersensitivity is normally suppressed by regulatory T cells, which maintain airway tolerance and represent a major pathway proposed to contribute to the maintenance of immune homeostasis in the airways. Bronchial asthma can result from a loss of regulation of autoreactive T cells. Failures of T reg cell-mediated regulation include: inadequate numbers of T reg cells owing to their inadequate development, proliferation or survival; defects in T reg cell function that is intrinsic to Treg cells; and resistance of pathogenic effector T cells to suppression by T reg cells owing to factors that are intrinsic to the effector cells or factors that are present in the inflammatory milieu and that support effector T cell resistance. DC, interleukin; TGFβ, Th17. The aim of the present study was to determine circulating T regulatory cells defined by the CD4, CD25, protein Foxp3 in the peripheral blood and their role in the severity evaluation of bronchial asthma in children. |