الفهرس 
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Abstract
Respiratory distress syndrome is one of the most common lung disorders in fterm infants, where RDS represents the single most important cause of mortality morbidity.
Fibrin deposition and many inflammatory factors have been demonstrated in pulmonary microcirculation and in the small airways. Many studies showed that rivation of the clotting system is involved in the pathogenesis of RDS. Clotting ’tors such as protein C, protein S have been known to playa role in the coagulation ess in RDS.
Recently, protein Z which is a vitamin k dependent protein, was added to these ctors. Hence, the aim of this study was to evaluate plasma protein Z levels in tterms suffered from RDS, healthy preterm infants and healthy full term infants fore vitamin kl administration (on day 1) and compare it with its levels after lamin kl administration (on day 3) in order to assess plasma protein Z level in Jdied groups, and if its decrease in RDS group contribute to a prothrombotic ndition in the form of activation of the coagulation system which lead to fibrin rosition in the pulmonary microcirculation and in small airways of the preterm wboms with RDS.
This study was conducted on 45 newbom infants who were recruited from lZan Mubarak Minia University Hospital from 6/2008 to 11/2008.
They were divided into 3 groups: Group (I): 15 healthy pre term control wboms (from delivery room). Group (II): 15 healthy full term control newborns om delivery room). Group (III): patients group: comprised 15 preterm newborns a developed RDS (from neonatal intensive care unit).
For each newborn included in the study, a venous blood sample was thdrawn before vitamin K 1 administration on day 1, another sample was 66.