الفهرس 
HOMOCYSTEINEOnly 14 pages are availabe for public view
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Abstract
Homocysteine is a sulfur containg amino acid that is generated during the
conversion of methionine to cysteine. The normal ranges of homocysteine
is from 5 to 15μmol/L. Multiple cofactors and enzymes are needed for the
metabolic pathways of homocysteine such as vitamin B12, B6, folate,
5,10-methylenetetrahydrofolate reductase enzyme, cystathionine -β-
synthase enzyme. Thus deficiency of these cofactors due to genetic or
acquired factors may cause hyperhomocysteinaemia which is mild to
moderate elevation of homocysteine in the blood or serum.
Hyperhomocysteinaemia was recently found to be related to different
dermatologic diseases such as: Psoriasis, vitiligo, Behcet’s disease,
systemic lupus erythematosus, scleroderma, Raynaud’s disease, livedoid
vasculopathy, purpura, wounds and squamous cell carcinoma. The aim of
the study is to elaborate the role of homocysteine in different
dermatologic diseases.
Keywords:
Homocysteine, Cystathione -β- synthase enzyme, 5,10-
methylenetetrahydrofolate reductase enzyme.