الفهرس 
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Abstract
Psoriasis is one of the commonest immune-mediated inflammatory disorders, affecting 2–3% of the population, characterized by erythematous scaly patches that affect the scalp, trunk, extensor surfaces of the limbs and the genital area.
Its etiology is still unknown, while genetic, metabolic and immunological mechanisms have been recommended as its causes. The pathogenesis of psoriasis includes increased T lymphocyte activity with auto- or super-antigen presentation and keratinocyte hyperproliferation due to the release of cytokines and chemokines from activated T lymphocytes.
Many studies suggest that lipid metabolism may play a role in pathogenesis of psoriasis. Lipid metabolism disorders in psoriasis increase coincidence of cardiovascular diseases including heart failure, myocardial infarction, cardiovascular hypertension and diabetes and this justify high mortality and morbidity particularly in patients with severe and prolonged disease.
In this case-control study, 50 psoriatic patients were randomly selected as case group and 50 healthy individuals who were age and sex matched were selected as a control group. All subjects were sent to the hospital laboratory for assessment of serum TG, CHO, HDL, LDL and VLDL.
The results of our study showed statistically significant increase in serum TG, CHO, VLDL levels of psoriatic patients when compared with those of the controls. There were 58% of psoriatic patients suffering from dyslipidaemia, however in the control group dyslipidemia was found only in 36% , so there were statistically significant occurrence of dyslipidaemia in patients when compared with controls, this dyslipidaemia was significantly correlated with age group>40 years .
Dyslipidaemia in psoriatic patients occurred in all components of lipid profile, however in the control group, the only dyslipidemia was in HDL level, so in cases, when compared with controls, the only statistically significant dyslipidaemia was in the level of TG, CHO and VLDL .Also there was higher serum TG level parallel with increased disease intensity and duration.
In Conclusion, our results indicated that psoriasis is an independent risk factor for hyperlipidemia and it’s possible subsequent squeals such as cardiovascular events. Hence, we recommend early screening of these patients for lipid abnormalities at presentation and during follow-up. Also we recommend treatment of hyperlipidaemia in psoriatic patients to prevent atherosclerosis and its complications. However, larger future studies are required to explore the effect of administrating lipid-lowering drugs particularly for, sever psoriatic cases in management of disease and prevention of cardiovascular events.