الفهرس 
الغلافOnly 14 pages are availabe for public view
 |  | from | 174 |  |  |
| | | from | 174 | | |
Abstract
Being cancer as a major threat to the public health so the recent considerable interest to get potential antitumor agents via synthesis, functional elucidation, and biological evaluation of different classes of component including various flavin analogs motivate our mind to design and develop flavin analogs as potent antitumor agents showing a higher selectivity towards tumor cells. Therefore, the main objective of this study is to design different flavin, flavin-5-oxide and alloxazine compounds revealing significantly potential antitumor activities against different tumor cell lines.
The main achievements of this study can be summarized as follows: design, synthesis, antitumor activity, and AutoDock study, which were carried out for 10¬alkyl-2-deoxo-2-methylthioflavin-5-oxides, 1 0-alkyl-2-N-(substituted amino) / 2¬heterosubstitued-2-deoxoflavin-5-oxides, 2,2’-(piperazine-1 ,4-diyl)bis( I O-methyl¬2-deoxoflavin), 10-alkyl flavins, 2-amino-2-deoxo-alloxazines, 10-alkyl-2-deoxo¬2-methyl th io- flavi ns, 1 O-alkyl- 2-deoxo- 2- hydrazono- flavi ns, 2-(2-substituted benzylidenehydrazono )-1 0-alkyl-2-deoxo- flavins.
Namely, 10-alkyl-2-deoxo-2-methylthioflavin-5-oxides have been
synthesized via nitrosative cyclization of 6-(N-alkylanilino )-2-
methylthiopyrimidine-4(3H)one. 2-N-(substituted amino) / 2-heterosubstitued-2¬deoxoflavin-5-oxides, 2,2’-(piperazine-1 ,4-diyl)bis(l 0-methyl-2-deoxoflavin), 2¬amino-2-deoxo-alloxazines and 2-hydrazono derivatives were prepared by nucleophilic replacement reaction of the 2-methylthio moiety using different amines, piperazine, ammonium acetate and hydrazine hydrate, respectively. 10¬alkyl-2-deoxo-2-methylthio-flavins were prepared by reduction of 1O-alkyl-2¬deoxo-2-methylthioflavin-5-oxides. 10-alkyl-2-methylthio 10-alkyl flavins were obtained by oxidative or acidic hydrolysis of 2-methylthio derivatives.