الفهرس 
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Abstract
The present study aimed to evaluate the antiviral and anticancer potentials of some Egyptian snakes and scorpion venoms as well as the L-amino acid Oxidase concerning the venom cytotoxicity to normal cells and lab animals. Assessment of venoms cytotoxic effect revealed that all of test venoms have a prominent cytotoxic effect to both cancer cell lines (CACO-2 and MCF -7) and also reported that the cytotoxic effect of all venoms to cancer cells extremely exceeds that to normal cells (MRC-5), that differences reach up to 80 fold in case of LAO enzyme and up to 63 fold in case of Leiurus scorpion venom. apoptotic gene regulation was assessed using semi quantitative RT-PCR and results revealed that there is a marked positive up regulation for pro apoptotic genes (P53 & BAX) post treatment with CC, NH, Leiurus venom and LAO enzyme. Also positive down regulatory effect for anti apoptotic gene (Bcl-2) was recorded post cell treatment with CC and Leiurus scorpion venom as well as in cells pretreated with LAO enzyme. A marked anti cancer effect was recorded post mice treatment by different test venoms especially for Cerastes cerastes and Naja nigricollis venom, this appeared in marked decrease in TLC comparing to non treated groups as well as marked increase in immune regulatory cells (Lymphocytes & Monocytes), marked change in liver enzymes directed toward the normal values, marked decrease in size of tumor mass, marked decrease in ascitic fluid volume and also in EAC count in venom treated groups. Also there are marked differences in body weight directed toward the normal in venom treated mice and also results showed marked increase in the mean survival time of venom treated mice than untreated groups. Antiviral activity evaluation recorded a marked reduction in HSV-II titer by 30% in case of treatment of vero cells by different snake venoms and 40% for Leiurus scorpion venom while treatment of cells with LAO enzyme reduced the virus titer by 15%. Regarding VSV antiviral activity of test venoms, data revealed reduction in the virus titer by 10% in case of LAO, 30% in case of Naja nigricollis treatment and 15% reduction in other test venoms. Both snake and scorpion venoms even LAO enzyme tend to record a more virucidal potentials compared with antiviral potentials. All venoms recorded 100% depletion in VSV titer 6 hr post virus treatment with different test venoms and 75% reduction for cerastes cerastes venom. While HSV depleted titer was 50% for Cc, N.nig and 65% for other test venoms 6 hr post treatment.