الفهرس 
In vivo Evaluation of Colon Specific Drug Delivery System in Rats
Colonic MicrofloraOnly 14 pages are availabe for public view
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Abstract
Colon specific drug delivery via the oral route has attracted much interest in terms of local treatment of diseases such as ulcerative colitis, crohn’s disease, colon cancer and amebiasis. Also, colon targeting has the potential for improving the oral bioavailability of peptide and protein drugs susceptible to acidic or enzymatic degradation in the stomach or small intestine. Delivery of a drug molecule directly to its site of action may allow a reduction in dose, and consequently a reduction in potential systemic side effects, which are major issues in clinical practice.As a site for drug delivery, colon offers a near neutral pH, reduced digestive enzymatic activity, a long transit time, an increased responsiveness to absorption enhancers and enormous amount of microflora. There are various proposed strategies to deliver orally administered drugs specifically to the colon including, formation of a prodrug, microflora activated system, time-dependent system, pH dependent system, combined pH- and time-dependent system and pressure-dependent system.