الفهرس 
AIM OF THE WORKOnly 14 pages are availabe for public view
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Abstract
Summary
Summary
This work is composed of four main chapters.
The first chapter: introduction
In this chapter, a literature survey was carried out and included the following of
items:-
a) Introduction about importance of hydrazone oximes.
b) Importance of oximes and modes of bonding of oxime in metal
complexes.
c) Defintion, nomenclature and preparation of hydrazones.
d) Importance of hydrazones and their metal complexes in the following
fields of applications:-
1- Biological application: Antitumor, anti-mycobacterial and antimicrobial
activity.
2- Pharmaceutical application: Anti-inflammatory activity, hydrazones in
treatment of iron overload diseases, antimalarial, anti-trypanosomal and
anti- convulsant.
3- Catalytic applications: In many fields such as some polymerization
processes and some chemichal reactions.
4- Analytical applications: Such as separation and determination of traces
of metals and determination of some species in pharmaceutical
formulations.
The second chapter : Review of literature on hydrazones, oximes and
hydrazone oximes.
This chapter included the following items:
Summary
1- Aliterature survey was carried out on hydrazones which include bidentate,
tridentate, teradentante, pentadentate, hexadentate, octadentate and
nonadentate hydiasone ligands and their corresponding metal complexes.
2- Aliterature survey was carried out on oximes which include types of
oximes: simple, carbonyl, vicinal, phenol, hydroxy, imine, pyridine and
amine oximes.
3- Literature survey and some examples on hydrazone oximes.
The third chapter: Experimental
In this chapter, the methods used for the preparation of new hydrazone
oxime ligand (isonicotinoyl hydrazone oxime) (H2L), (1) and preparation of its
metal complexes for copper(II), nickel(II), cobalt(II), manganese(II), zinc(II),
cadmium(II), mercury(II) and iron(III).
The techniques used for characterization of new ligand and its complexes were
also described which included: elemental, thermal analyses, infrared spectra,
proton magnetic resonance (1H-NMR), mass spectra, electronic absorption spectra
(UV-VIS), electron spin resonance (ESR), magnetic also described biological
activity of the hydrazone oxime ligand and its metal complexes and determine the
invitro cytotoxicity properties against breast cacer (MCF-7) and colon carcinoma
(HCT) tumoral cell lines.
The fourth chapter:- Results and discussion
The analytical and spectral studies showed that the ligand isonicotinoyl
hydrazone oxime behaves as anutral bidentate ligand.
The second, the ligand behaves as neutral tridentate.
The last mode, the ligand behaves as monobasic tridentate.