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Abstract celiac disease is one of the most common food intolerance the only effective treatment forceliac disease is astrict adherenceto agluten free diet throughout the patient’s lifetime gluteh-free products such as bread are not widely available and are usually more expensive than their gluten containing counterparts therefore there is an urgent need to develop high-quality gluten-free products phenylketonuria (pku) is an inborn error of phenylalanine metabolism that occur in new born in the absence of treatment during infancy most persons with this disorder will develop servere retardation |