الفهرس 
PRETERM LABOROnly 14 pages are availabe for public view
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Abstract
Preterm birth is defined by WHO as delivery of an infant before 37 completed weeks of gestation. The incidence of preterm birth is 5% to 10% of births. About 30% of preterm births are unexplained and spontaneous-multiple pregnancies accounts 30% of cases. Other risk factors include genital tract infections, PPROM, APH cervical incompetence and congenital uterine anomalies representing 20 to 25% of cases. The remaining 15-20% are attributed to induced PTL secondary to hypertension, IUGR, congenital abnormalities, trauma and medical disorders of pregnancy.
This case control study was conducted at Ain Shams University Maternity Hospital, to evaluate the level of C-reactive protein, cholesterol, triglycerides, HDL, LDL in patients with spontaneous preterm labor. In this study 90 pregnant women were selected and divided into three groups, control group included 30 women with term labor, early PTL group included 30 patients with established preterm labor at less than 34 weeks’ gestation and late PTL group included 30 patients with established preterm labor at 34-37 weeks gestation.
In this study the women were selected with established labor at child bearing period (20-35 years) with average body mass index, patients with polyhydraminos, oligohydraminos, multiple gestations or any congenital uterine anomalies, hypertension, diabetes mellitus, chronic renal failure, anemia and also, fetal congenital anomalies were excluded from the study.
On admission all subjects were subjected to verbal consent, detailed history and examination and withdrawal of 5ml of random venous blood sample for measurement of complete blood count, CRP level, total cholesterols, triglycerides, LDL and HDL.
Regarding to our study there was no significance difference between early and late preterm groups and control group regarding maternal age and parity (P > 0.05). While, there is highly significant difference between three groups regarding gestational age (P< 0.001).
This study showed that there was a significant association between three groups regarding previous preterm labor in the history of the cases and increased risk of preterm labor (p< 0.05). While, there is no statistical significance between three groups regarding previous abortion (P> 0.05).
The current study, depicated that there is no association between smoking and increased risk of preterm labor (P > 0.05).
Regarding to this study there was no significant difference between three groups regarding anemia and while blood cells with increased risk of spontaneous preterm labor (P > 0.05).
This study showed that there was no statistical significant difference between three groups regarding positivity C-reactive protein and increased risk of spontaneous preterm labor (P > 0.05).
The current study showed that there was statistical significant between 3 groups regarding cholesterol level with early PTL group higher than both late PTL and control groups (P < 0.05).
Also, there was statistical significant between 3 groups regarding triglyceride level with early PTL group higher than the other control and late preterm group
(P < 0.05).
This study denoted that there was statistical significant between 3 groups regarding LDL level with early PTL group higher than other 2o groups (P < 0.05).
However, there was no statistical significant between 3 groups regarding HDL level (P > 0.05). This may be due to that HDL has a protective effect against oxidative stress. Also, there was highly statistical significant between all PTL groups and control group regarding LDL level
(P < 0.001).
However, there was no statistical significant between all cases of PTL groups and control group regarding to HDL level (P > 0.05).