الفهرس 
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Abstract
Plasma MDA level was significantly higher (P< 0.0001) in SCD
cases compared to controls and the mean total antioxidants level, vitamin
E, NO and paraoxonase were significantly lower among SCD patients
compared to controls (p<0.05). No significant differences in the mean
level of NO, paraoxonase and TAO and MDA in SCD males when
compared with SCD females (P
˃
0.05). No significant differences in the mean level of NO, paraoxonase and TAO and MDA in SCD cases on HU
when compared with SCD cases not receiving HU ( P
˃
0.05).
For the Cut-off values of antioxidant enzymes for prediction of
occurrence of VOCs whatever its frequency we found that area under the
curve of NO was 0.782 versus 0.701 for paraoxonase and 0.650 for TAO
and this difference was statistically significant (p=0.006).
Conclusions: Increased level of lipid peroxidatation product MDA was
found in SCD patients accompanied with significantly lower activity
level of antioxidant enzymes indicates that SCA patients produced greater
quantities of reactive oxygen species formed by sickle erythrocytes which
are less likely to be removed effectively with the endogenous mechanism.