الفهرس 
AknowledgmentOnly 14 pages are availabe for public view
 |  | from | 266 |  |  |
| | | from | 266 | | |
Abstract
Nephrotic syndrome is a disease characterized by proteinuria,
hypoalbuminemia, hypercholesterolemia and edema.
The nephrotic syndrome is usually involving children between
ages of 2 – 10 years. Primary nephrotic syndrome is more common
in children less than six years of age (80% of cases) while
secondary nephrotic syndrome predominates for patients older
than six years old.
The present study was conducted in Abo El Reish pediatric
hospital and Beni Suef university hospital, aiming to study the role
of ACE-Is and ARBs and statin in reduction of proteinuria and
hyperlipidemia as a total management of nephritic patients .
The study was designed as studied cases and control cases, each
group included 20 nephritic children cases was collected randomly.
229
ENGLISH SUMMARY
Study group was treated with triple therapy of ramipril and
losartan and atorvastatin in addition to prednisolone and control
group treated with captopril and prednisolone only.
Both studied and control cases were subjected to general
examination including blood pressure, clinical examination including
edema and laboratory investigations including serum albumin, serum
cholesterol, albumin in urine and P/C ratio, LDL-level in blood .
The results of our study showed that studied cases that were
treated with triple therapy led to management of proteinuria and
hyperlipidemia , decreasing of corticosteroid doses and avoid its side
effects as weight and hypertension. Also this study showed that
capsule dosage form was rapidely absorbed and more bioavailable
than tablet dosage form in treatment of nephrotic children patients.