الفهرس 
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Abstract
he goal of this work was to investigate the mechanism based inhibition of selective model activities for some major xenobiotic-metabolizing enzymes, namely CYP1A2, 2A6, 2C8, 2C9, 2C19, 2D6 and 3A4 by certain pesticides. Chlorpyrifos, fenitrothion, malathion, phenthoate and profenofos were chosen for the investigation of mechanism based inhibition of CYP1A2, CYP2A6 and CYP2C8 (atrazine in addition for CYP2C8), fenitrothion, malathion, phenthoate, hexaflumuron, glyphosate, chlorfluzuron were chosen for investigating CYP2C9, chlorpyrifos, fenitrothion, phenthoate, abamectin, deltamethrin, lamda-cyalothrin, fenvalerate for CYP2C19, chlorpyrifos, phenthoate, profenofos, lamda-cyhalothrin, fenvalerate, deltamethrin and carbendazim for CYP2D6 and chlorpyrifos, fenitrothion, phenthoate, lamda-cyhalothrin and atrazine for CYP3A4. The results showed that there was not considerable decrease in the IC50 values except for fenitrothion towards CYP2A6, the IC50 values being 23.99 μM for 2-minutes and 4.33 μM for 15-minutes preincubation indicating mechanism based inhibition. Some other pesticides showed decrease in the 15 minutes preincubation IC50 values like chlorpyrifos towards CYP2A6, phenthoate towards CYP2C19 and CYP2C9 and profenofos and carbendazim towards 2D6 however, values were more than 10 μM indicating mechanism based inhibition but of weak potency.