الفهرس 
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Abstract
Cancer is the abnormal growth of cells in our bodies that can lead to death. Antitumor activity is one of the health-promoting effects attributed to FM containing probiotic bacteria and RE.
This study was conducted to evaluate the possible antitumor activity of FM and/or RE against EAC in female Swiss albino mice.
Mice were fed 4 weeks with FM, RE or their combination, injected with EAC cells and continued receiving their diet throughout the experimental period (60 days). Other groups were fed with the same diet and injected with the standard drug cisplatin one day post tumor injection.
The effect on the MST, %ILS and packed tumor cell volume was evaluated. The percent increase in body weight and tumor cell count were determined on the 7th, 14th, 30th and 60th days after tumor induction. Simultaneous alterations in the haematological profile (Hgb and total WBCs counts) and some biochemical parameters (GSH, LPO and TNF-α) were estimated on the 0, 14th, 30th and 60th days post tumor induction. The results obtained were comparable with that of the standard drug cisplatin.
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Feeding mice with FM, RE or their combination showed a decrease in the % increase in body weight, total and viable tumor cell count, LPO and TNF-α levels, whereas GSH level was increased. The survival rate was not significantly improved and also the packed tumor cell volume was not decreased. They were able to keep the Hgb count at normal levels, while the WBCs were decreased.
Cisplatin combination with the FM, RE or both, showed a significant increase in the life span which is confirmed by a significant increase in the MST and a decrease the packed tumor cell volume, in comparison to the +ve control group, which was not observed when no cisplatin was injected. Also, the body weight, total and viable tumor cell count, LPO and TNF-α levels were decreased, while the GSH level was increased more than observed with the +ve control group. The CIS/FM and CIS/R groups significantly increased the Hgb count at day 14. The WBCs count was decreased.
It is important to note that the cisplatin effect was greatly improved by its combination with FM, RE or both through a significant decrease in the body weight, total and viable tumor cell count, packed tumor cell volume, LPO and TNF-α, and a significant increase in the GSH level. The CIS/FM group significantly increased the survival of the mice more than observed with the CIS group.