الفهرس 
Frequency of leukoaraiosisOnly 14 pages are availabe for public view
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Abstract
Background - leukoaraiosis is independently associated with an increased risk for recurrent stroke, vascular death, hemorrhagic complications and cognitive decline. Several studies have demonstrated relationships between cardiovascular risk factors and baseline burden of leukoaraiosis. There has been little study of change in risk factors in relation to change in leukoaraiosis burden.
Objective -Studying the effect of change in multiple cardiovascular risk factors on progression of leukoaraiosis in patients with previous stroke or TIA.
Methods -Patients with leukoaraiosis who have serial brain imaging with at least one year interval were enrolled in this retrospective cohort. We recorded demographic data, risk factors for stoke assessed serially with a minimum one year interval including systolic and diastolic blood pressure, fasting blood sugar, HbA1c, lipid profile, smoking condition, medication use and stroke recurrence. Leukoaraiosis changes on CT or MRI were assessed using the white matter lesion change score. Logistic regression analysis was performed looking for predictors of leukoaraiosis progression examining the clinical variables above in univariate and stepwise multivariate analysis.
Results - An increase in LDL level significantly predicted decreased risk of leukoaraiosis progression. Increasing total cholesterol level was found to be a borderline significant predictor of decreased risk of leukoaraiosis progression .We failed to find a relation between change in blood pressure, smoking status, Age, sex and progress in leukoaraiosis burden . Conclusion: LDL has an inverse relationship with leukoaraiosis progression. higher lipid levels may result in less progression by having a stabilizing effect on the microcirculation although more study is required.