الفهرس 
IntroductionOnly 14 pages are availabe for public view
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Abstract
Myocardial ischemia/reperfusion (I/R) induces a catastrophic cascade of events, referred to as I/R injury, which under specific circumstances can lead to multiple organ damage. Increased production of reactive oxygen species, necrosis, vascular injury, and increase in mucosal permeability are some of the prominent features of I/R injury.
The present study was an attempt to investigate the possibility for protection of ischemic heart against myocardial I/R injury utilizing two therapeutic strategies. The first one was the protective effects of Complement-1 esterase inhibitor (C1-INH) infusion while the second was the oral administration of a combination of omega-3 poly unsaturated fatty acid (PUFA) and aspirin. This study also attempts to investigate the cardioprotective effect of the combination of both strategies against myocardial I/R injury.
The complement-1 esterase inhibitor (C1-INH), showed cardioprotective effect against myocardial I/R induced injury in isolated hearts especially when given during the onset of reperfusion. Daily oral combination of omega-3 fatty acids and aspirin administered for 21 days prior to induction of I/R injury showed potential cardioprotective effects against I/R induced injury. Combination of C1-INH together with prior administration of omega-3 fatty acids and aspirin combination for 21 days demonstrated a synergistic effect on the cardioprotection potential showing the most significant cardioprotection against I/R-induced injury when compared with other treated groups, separately.