الفهرس 
Introduction & Aim of the workOnly 14 pages are availabe for public view
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Abstract
Anticholinesterase insecticides are possibly the most widely used insecticides worldwide that may cause serious poisoning either suicidal on accidental exposure. Acute severe poisoning due to anticholinesterase insecticides often present as medical emergencies, which require management in intensive care.
This study was carried out to study the effect and outcome of fresh frozen plasma and magnesium sulfate plus routine management in the form of gastric lavage, atropine and OXlmes in the management of Organophosphorus poisoning.
A total of 64 patients with Organophosphorus insecticide poisoning were available for this study. The patients were admitted to Poison Control Centers of Minia University Hospital, during the period from the 1 SI of Ylarch 20 I 0 to the I sl September 2011.
Group 1 :( control group):- Sixteen patients of both sexes treated from or poisoning with routine management in the form of atropine and oximes.
Group II : Sixteen patients of both sexes whom treated with magnesium ’ulfate plus routine treatment as control group.
Group III : Sixteen patients of both sexes whom treated with routine treatment as control group plus Fresh frozen plasma
Summary
Group IV: Sixteen patients of both sexes whom treated with routine treatment as control group plus Fresh frozen plasma and magnesium sulfate like the previous group
Data collected in a sheet for every patient and the study were tabulated and statistically analyzed
It included data regarding age, sex, and area of residence (Urban or rural). In addition, the mode of poisoning were analyzed. Summer crop spraying season (September to February) or winter (March to August); identity of insecticide; and delay time of exposure were recorded.
Clinical evaluation of the patients was carried out regarding the eye, skin, temperature, respiratory system, CVS, gastrointestinal tract, urinary system, and eNS.
-Investigational Parameters: A three milliliters venous blood sample was collected from each patient on admission just after the diagnosis of poisoning and before any medication is given. Serum was separated and then used for estimation of the following tests;
• Serum chlinesterase Level.
• Liver Function Tests.
• Renal Function Tests ..
• Serum Electrolytes: Sodium, magnesium and potassium levels.
• Serum Glucose Level
with routin esium sulfate
ce (Urbar or ummer crop to August);
ing the eye, act, urinary
lood sample diagnosis of parated and
Summary
, - Total dose of atropine was measured in each patient. , -Total dose of oximes was measured in each patient.
t -Magnesium sulfate if given or not and doses.
t - Total doses of fresh frozen plasma if gi ven.
The results of this study were tabulated and statistically analyzed and revealed:
A total of 64 patients with Organophosphorus insecticide poisoning were available for this study. Age was ranged from 18 years to 60 years. The most affected age group was from 22 to 36 years in both sexes. Twenty three of patients were female and 41 were male. About 68.75 % ,from urban area, and 31.25 % from rural areas. Oral ingestion was found to be the most common route for poisoning. Forty patients under study were intoxicated in the summer crop spraying season and 24 in winter.
The most frequent condition of poisoning was attempted suicide (51 out of 64 patients) (79.6%). 32 male patients and 19 female patients.
There were 5 different types of Organophosphorus e insecticide agents involved in the intoxication. Malathion (19 cases), dimethoate (10 cases) and fenthion (7 cases) were the most common agents involved. Others were chlorpyrifos (6 cases), and diazinon (6 cases).