الفهرس | Only 14 pages are availabe for public view |
Abstract Benzylation of compounds 288a,b with benzyl chloride under the previous conditions gave the S-benzylated bis-pyrimidines 293a,b in high yields (Scheme 94). Upon treatment of compound 293a with sodium ethoxide in ethanol, it underwent intramolecular Thorpe- Ziegler cycIization and partial oxidation to furnish thienopyrimidine Scheme 94. Synthesis of biS-{thienO[2,3-djpyrimidin-4(1H)_one} 294. Treatment of 288a with ethyl bromoacetate, in aq.KOH furnished bis-{ thieno[2,3-djpyrimidin-4(1H)_one} 295 (Scheme 95). |